Research projects and contracts

Active projects

H2020-WIDESPREAD-2020-5 Teaming Phase 2 project No. 857287 Baltic Biomaterials Centre of Excellence (BBCE) (2020-2026).

Coordinator: Asoc.prof. Dr.sc.ing. Janis Locs, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The Baltic Biomaterials Centre of Excellence (BBCE) overall objective is to develop a joint BBCE for advanced biomaterials development based on the long-term strategic cooperation between Riga Technical University, Latvian Institute of Organic Synthesis , Rīga Stradiņš University and LLC Rīga Stradiņš University Institute of Stomatology, on the one part, and AO Research Institute Davos, Switzerland and Friedrich-Alexander University of Erlangen-Nuremberg, Germany, on the other part. The activities of the BBCE will provide an opportunity to combine existing expertise and infrastructure to create critical mass and excellence in the development of biomaterials for bone regeneration and solutions for creative biomedical applications. The expected impact of the BBCE project through Teaming Phase 2 in long term will be achieved through fruitful cooperation between the BBCE core partners in Latvia and industry (including SMEs) bringing the high performance products into the market, increasing scientific excellence, elevating the impact factor of peer-reviewed publications and Hirsch index in the field of biomaterials. Collecting ""critical mass"" of high level scientists and/or technology developers will be achieved ensuring career development to provide highly-qualified staff at BBCE core partners able to work in a multinational and interdisciplinary environment and capable to cope with their future career demands in an efficient and innovative way

H2020-WIDESPREAD-2020-5 Twinning project No. 952347 Rising competitiveness of early stage researchers and research management in Latvia (RISEus2)” (2021-2023).

Coordinator: Asoc.prof. Dr.sc.ing. Janis Locs, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Early stage researchers (ESR) from low performing countries are less competitive in the international scientific area than ESR's form internationally-leading counterparts. This is strongly related not only to the applicants itself, but also to the environment in which they were seeded as next generation researchers - meaning Universities. The competitiveness in scientific area is related to well measurable indicators, such as impact factors, papers in high-ranking journals, H-index, competitive funding, etc. Hence RISEus2 project´s Overall Objective is to significantly strengthen the research management and administration skills of RTU RBIDC leading staff and increase the research profile of ESR hosted in RTU RBIDC in the area of biomaterials development for bone tissue replacement and regeneration based on the long-term strategic cooperation between RTU RBIDC and three internationally leading counterparts: AO Research Institute Davos, Switzerland (ARI), Institut National Polytechnique de Toulouse CIRIMAT, France (INPT-CIRIMAT) and FORM-Lab Frankfurt Orofacial Regenerative Medicine, Goethe University Frankfurt, Germany (GUF). The purpose of RISEus2 is to create links and provide training which will ensure that RTU RBIDC will gain new knowledge and approaches of biomaterials research planning, implementation and exploitation. This will include methods, tools, equipment and effective infrastructure exploitation necessary to develop excellence in biomaterials research, that will boost the cooperation with the industry, thus becoming internationally competitive and attractive. The main RISEus2 activities include two way collaborative visits, mobility of staff, summer and winter schools, workshops at partner institutions, strengthening the visibility and cooperation with industry and intensive dissemination and outreach activities.

 

COST European cooperation in Science & Technology, CA18238 “European transdisciplinary networking platform for marine biotechnology (Ocean4Biotech)” (2019-2023).

Project partner: Dr.sc.ing. Arita Dubnika - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering      

The overall aim of Ocean4Biotech is to bring together experts in the field of marine biotechnology, to provide a platform for sharing experience, knowledge and technologies, and to design a roadmap for a more efficient and rapid development of marine biotechnology research in Europe and beyond. To best of our knowledge, such a large, diverse and geographically dispersed network of experts in marine biotechnology does not exist. Since marine biotechnology is still in its infancy, we believe this is the optimal timing to create this efficient, operational, motivated, inclusive and sustainable network with a serious and ambitious commitment for proactive dissemination and science communication activities.

EuroNanoMedIII project “NANO delivery system for one-shot regenerativa terapy of peri-implantis” (ImlpantNano) (2020-2023).

Coordionator: Dr.sc.ing. Jānis Locs, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The use of dental implants, including titanium (Ti) and its alloys, to restore missing teeth has become a routine method of treatment. However, complications associated with inflammation around the implant, such as periimplantitis, are becoming more common. The main goal of the multidisciplinary project ImplantNano is to create innovative, ready-to-use nano-composite drug delivery systems for the effective treatment of periimplantitis. The project will improve previously developed nano-composite drug delivery systems based on a biodegradable polymer with the aim of granting bone regenerating properties and ensuring control of the release profile of antibacterial drugs. Within the framework of the project, antibacterial calcium phosphate nanoparticles containing Ga3+ ions will be synthesized at the RTU RC RBIDC and will be used as nano-composite fillers.

M.ERA.NET Call 2019 “Bioactive injectable hydrogels for soft tissue regeneration after reconstructive maxillofacial surgeries (INJECT-BIO)” (2020-2023).

Coordinator: Dr.sc.ing. Arita Dubnika - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Oral soft tissue regeneration after ablative surgery or trauma is still a challenging goal in today’s clinical routine. Currently available biomaterials in the market act as soft tissue fillers, but cannot ensure the bioactive response and/or ingrowth of gum-derived cells. In INJECT-BIO project, the development of advanced biomaterials and drug delivery systems for oral soft tissue regeneration will be investigated by applying Halomanas levan and bacterial cellulose-based injectable hydrogels containing IGF-1 and cannabis extract/cannabidiol liposomal simultaneous delivery systems. The project consortium unites the expertise, complementary skills and infrastructure of researchers and professionals from 5 countries – Latvia, Lithuania, Israel, Turkey and Czech Republic. The INJECT-BIO project will generate advanced know-how and knowledge of hydrogel-cell interactions leading the product till TRL4, giving a great potential for INJECT-BIO results to be transferred in the market.

H2020-MSCA-ITN-2019 project No. 860462 “ Precision medicine for muscolo-skeletal regeneration, prosthetics, and active aging (PREMUROSA)” (2020-2023).

Project partner: Dr.sc.ing. Janis Locs, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Muscoloskeletal diseases are a major burden on individuals, healthcare and welfare systems. Treatment of muscolo-skeletal disorders is currently based either on prosthetic or regenerative surgical procedures, often involving medical device implantation. In both cases, individual tissue healing and regeneration, together with the appropriateness of the implanted device, markedly affect the outcome. A great improvement could be achieved by precision medicine, specifically designed on patient’s individual characteristics. This implies to combine the personalized clinical approach with individual ‘omic’ characterization and proper choice of medical device. The concept is “To take care with care”. This is the meaning of the Italian word “premurosa” and the ultimate goal of the ITN PREMUROSA project, aimed to train a new generation of scientists with an integrated vision of the whole value chain in muscolo-skeletal regeneration technologies and able to boost the necessary innovations to achieve precision principles in developing innovative devices and optimized clinical applications. This aim will be achieved by a “triple i” (interdisciplinary, intersectoral, international) approach of thirteen ESRs, who will benefit from an excellent scientific environment, up-date technologies and supervision by international leaders in the field. They will learn to integrate academic and industrial aspects and they will sharpen their experimental and complementary skills in a well-designed and diversified and unprecedented training program.

H2020-MSCA-IF-EF-ST Marie Sklodowska-Curie Actions Individual Fellowships project “Metabolites as immunomodulatory additives for biomaterials (Met4Bone)” (2020-2022).

Project leader: Dr. Kristaps Klavins - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The biomaterials are crucial for the surgical remediation of bone defects caused by various diseases. However, there are several risks associated with this treatment; first, the surgical procedure itself carries a potential risk of inflammation and bone infection, second, the bone replacement can fail requiring revision surgery. In fact, the host immune response to implanted materials and devices is the main factor that will determine a long-term functional outcome of the biomaterial mediated treatment. The main aim of this project is to develop novel biomaterials with incorporated metabolites as a potentially effective and safe strategy to modulate local immune response towards favourable outcomes of surgical bone remediation. This interdisciplinary project will combine the recent concept of metabolomics with the state of the art biomaterial design and research.

LIFE+ project “Alina Life Formulations in Open-Source Platform (LIFE ALFIO)” (2019-2022).

Project partner: Dr.sc.ing. Olita Medne - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The general objective is to reduce the impact of toxic chemicals on the environment and human health by reducing and replacing toxic biocidal and VOC paint and coating components with safe, sustainable and new organoclay material. Specific objectives of the project:
1. To pilot the use of organoclay additives in 16 environmentally friendly, reduced VOC and biocide-free paints and recipes as a transferable solution in the production of paints and coatings.
2. To promote and make easily transferable VOC and biocide reduction opportunities by developing an online platform: 1) for publishing paint formulations, 2) for transparency and traceability of paint and coating components,3) for industry communication.
The project will provide a toolkit for the paint and coating industry to replace toxic chemicals. The new approach to a public online platform with published formulations and the ability to track components will increase industry knowledge and facilitate transparency of product values.

Fundamental and Applied Research Project No lzp-2019/1-0005 “Injectable in situ self-crosslinking composite hydrogels for bone tissue regeneration (iBone)” (2020-2022).

Coordinator: Assoc. Prof., Dr.sc.ing. Dagnija Loca, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Musculoskeletal system diseases (osteoarthritis, osteoporosis etc.) and disorders are the second largest contributor to disability worldwide. The overall goal of iBone project is to develop novel injectable in situ self-crosslinking hydrogel for bone tissue regeneration, based on nanosized calcium deficient hydroxyapatite, ɛ-poly(L-lysine) and hyaluronic acid, simultaneously ensuring antibacterial effect and promoted bone regeneration. The novel hydrogels will be fabricated using calcium phosphate in situ synthesis in biopolymers solution. The physicochemical properties, in vitro antimicrobial activity, cytotoxicity and osteoinductive properties will be investigated. Results will be summarized in high impact Open Access publications and presented at international conferences. The research proposal matches with the Priority Directions in Science in Latvia such as Technologies, Materials and Systems Engineering for Increased Added Value Products and Processes and Public Health. Within iBone project novel injectable hydrogels will be developed (starting from TRL2 and ending up to TRL4) with a potential for transfer from laboratory to the market as high added value biomedical products or new technologies. The research results can give a beneficial impact on the Latvian national economy and public health sector and promote a development of sustainable modern healthcare system by improvement of the quality of life of patients who suffer from bone defects and disorders.

EuroNanoMed III project “NANOstructured oSteoChOndral scaffold: novel biomimetic tRiggErS for enhanced bone regeneration" (NANO-SCORES) (2018-2021).

Project leader: Assoc. Prof., Dr.sc.ing. Janis Locs - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Degeneration of the articular osteochondral tissues causes pain and decreased function leading to osteoarthritis. Till now, only one osteochondral scaffold (developed by two partners of the project consortium) has been translated in the clinical practice to restore the damaged joint surface. Results have been satisfactory for the cartilage layer, but regeneration of the subchondral bone by the scaffold has to be improved. The NANO-SCORES project aims to improve this clinically tested osteochondral scaffold by introducing two new nano-strategies: (i) nanostructured “ion banks” in the form of amorphous calcium phosphate granules with Sr and (ii) bioactive peptides, such as SDF1, PDGFBB, BMP2 and GDF5 bioconjugated to the scaffold.

Fundamental and Applied Research Project No lzp-2018/1-0238 “Future of synthetic bone graft materials - in vivo guided biosynthesis of biomimetic hydroxyapatite” (2018-2021).

Coordinator: Prof., Dr.sc.ing. Janis Locs, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Despite all the performed biomaterial related research for the last decades, more effective materials for regeneration of damaged bone tissue caused by aging, diseases, trauma and pathologies are still needed. Aim of the project is to develop synthetic bone regenerating material with excellent properties that are comparable with “gold standard”, i.e., natural bone. Material we are working with is biomimetic amorphous calcium phosphate. Amorphous calcium phosphate is considered to be the first inorganic phase, which form new bone tissue. Both amorphous calcium phosphate and natural bone mineral is mostly made of calcium and phosphorus elements. Nevertheless, natural bone comprises small amounts of other elements, e.g., magnesium, strontium, zinc, sodium, potassium and fluorine. Within framework of the project amorphous calcium phosphate containing these elements will be obtained, thus approaching natural bone in terms of composition, properties and performance.

Post-doctoral research projects 

European Regional Development Fund within the Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”.

 1)Bioactive synthetic dental enamel – the future of restorative stomatology (BioDEN)” 2020-2023

Project leader: Dr.sc.ing. Vita Zalite - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering, Project No. 1.1.1.2/VIAA/3/19/459

The most common oral disease is caries that in long-term leads to the loss of sufficient dental hard tissue, in addition, different accidents during lifetime of human can cause detriment of tooth part or even all tooth, thus leading to aesthetic problems. Restorative dentistry provides different artificial materials to replace lost tooth parts, but none of them show bioactivity. Therefore, the goal of the scientific project is to combine calcium phosphate material with organic phase in order to develop new biocomposites mimicking the natural tooth enamel. To obtain mechanically strong biocomposite, new technology, called cold sintering process, will be applied. Through reaching the scientific goal, novel methodologies will be developed and post-doctorate will be able to build her scientific capacity in multidisciplinary fields. Scientific articles and conferences will ensure approbation of the results. The implementation of the project includes calcium phosphate synthesis, preparation and characterization of composite materials by cold sintering process. The research project proposal goes under two scientific fields: engineering and technology (materials engineering), medical and health sciences (health sciences), therefore it has multidisciplinary nature. It is expected that the developed material could be used for further preclinical and clinical studies and finally transferred to industry

2) "Design of artificial lighting for phycocyanin production in bubble column photobioreactor." 2020-2023

Project leader: Dr.sc.ing. Agnese Stunda-Zujeva - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering, Project No. 1.1.1.2/VIAA/3/19/459

The objective is to develop efficient artificial lighting regime for Arthrospira cultivation in bubble column photobioreactor (PBR) to improve the synthesis of phycocyanin (C-PC). For the first time two-stage lighting and night illumination will be tested for Arthrospira cultivation that has shown promising results for other microalgae productivity and composition control.  The lighting profiles will be adapted to biomass and product building phases. Activities. 1) two-stage lighting and night illumination - batch study depending of process phase. 2) Scale-up to bubble column PBR, semi-batch study, PBR with immersed LED illumination development; 3) Adaptation of Arthrospira to specific light in long term. The obtained knowledge will increase understanding on various Arthrospira strain response to novel lighting regimes and effects of scaling-up (up to 200L). The investigated inner illumination and developed light source topology of PBR is important for various culture producers and can essentially save resources and decrease costs of biomass and product synthesis.

3) “Investigation of carbon containing materials and method development for heavy metal removal from water” 2018-2021

Project leader: Dr.sc.ing. Inga Jurgelāne, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The scientific aim of this project is to develop effective and environmental friendly adsorption materials with relatively low costs and laboratory size prototype for water purification from heavy metals. Shungite, hydroxyapatite and clays will be used as raw materials. The main tasks contain material preparation and characterization, adsorption of  Cu2+, Zn2+, Pb2+, Cd2+, Ni2+, Cr6+ and As5+  ions, regeneration of the used materials and development of laboratory size prototype.

4) “Application of cold sintering process for preparation of bioceramics and biocomposites with enhanced properties” (Nr. 1.1.1.2/VIAA/2/18/318) (2019-2021).

Project leader: Dr.sc.ing. Kristaps Rubenis RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

For a long time, scientists have tried to minimize sintering temperature of ceramic materials, therefore, the recently discovered Cold Sintering Process (CSP) have attracted great interest, since it allows to sinter and integrate various materials at temperatures below 300 °C. So far, CSP practically have not been used to produce bioceramics and biopolymer/bioceramic composites, although this method could substantially improve various properties of the respective materials as compared to the ones produced by conventional techniques. Therefore, the goal of the present project is to obtain bioceramics and biocomposites with improved mechanical properties and bioactivity by using the CSP. The main tasks include preparation of different bioceramic and biocomposite materials by CSP as well as their characterization. Through reaching the scientific goal, novel methodologies will be developed, and post-doctorate will build his scientific capacity in multidisciplinary fields and this knowledge will help him to become a mature researcher. The obtained results will be published in international peer-reviewed scientific journals with high impact factors and presented in relevant scientific conferences. It is expected that the developed materials will be used for the further clinical studies and in future will be transferred to industry.

5)  “Multifunctional calcium phosphate and biodegradable polymer composites for therapeutic bone tissue engineering” 2017-2020

Project leader: Dr.sc.ing. Kristine Salma-Ancane - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering, Project No. 1.1.1.2/VIAA/1/16/045

Repair and healing fractures caused by osteoporosis or cancer still remains a major clinical challenge in orthopaedic surgery. The scientific objective of proposed project is to develop novel multifunctional composites and composite hydrogels based on nanosized hydroxyapatite and biodegradable polymers such as ɛ- poly(L-lysine) or poly(vinyl alcohol) loaded with the antiosteoporotic agent strontium ranelate or the anti-cancer drug doxorubicin for bone fracture healing and effective local therapeutic treatment of osteoporosis or bone cancer. The composites and composite hydrogels will be developed by novel advantageous methodology using in situ synthesis of hydroxyapatite in drug containing polymer solution and spray drying technology or freeze-thawing technique. The physicochemical and mechanical properties will be investigated, as well as biodegradation, drug release kinetics, cytocompatibility study and antibacterial activity will be performed. The obtained research results can be transferred in the development of high added value bone graft substitutes which are potentially transferable from laboratory to the biomedical product industry. The implementation of the proposed project will provide new knowledge and know-how of biomaterials research and development for bone tissue engineering applications.

ERA-NET EU-LAC Health project “Efficient and affordable water treatment technologies to minimise waterborne diseases (2018-2020).

Project Partner: Asoc.prof. Dr.sc.ing. Janis Locs, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The project aims to produce and demonstrate on a field- scale several point -of-use water treatment technologies that will be specially targeted to rural communities, affordable and easy to use. Within the project specially coated membranes with increased efficiency, titanium oxides electrodes and novel hybrid UV microfiltration system will be designed and evaluated for their efficiency to neutralize bacterial, viral and protozoan pollution. 

 

Finished projects

European Regional Development Fund within the Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment” post-doctoral research project:

“Drug and growth factor dual delivery from different biomaterial carriers for bone tissue engineering (2ForBone)”. 2018-2020

Project leader: Dr.sc.ing. Arita Dubnika RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering. Project No 1.1.1.2/VIAA/1/16/048

The goal of the 2ForBone project is to develop an antibiotic drug and growth factor dual delivery systems on the basis of different biomaterial scaffolds (bioceramics, hydrogels and bone cements) and compare these systems, to develop better drug and growth factor biomaterial carriers than these, currently available for the bone tissue engineering in clinics. The study is designed in three stages, starting from material development till their characterization in vitro. Accordingly, direct comparisons among a material preparation and different characterization data (i.e. chemical, mechanical, release kinetics, cytotoxicity, etc) will be ensured. Project is implemented at RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre together with partner institutions: Biomaterials and Advanced Drug Delivery laboratory (Stanford University, USA BioADD), Laboratory of Pharmaceutical Pharmacology (Latvian institute of Organic synthesis, Latvia, LPP) and State Research Institute Centre for Innovative Medicine (Lithuania, IMC).

EuroNanoMed II project „PhOtocrosslinked hydrogels for guided periodontal TissUe Regeneration” (POsTURE) (2015-2018).

Project leader: Assoc. Prof., Dr.sc.ing. Dagnija Loca - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Periodontitis, a recognized disease worldwide, is a serious gum infection that damages soft tissue and results in loss of tooth-supporting alveolar bone. Regenerative periodontal procedures aim to reverse this damage by using both a bone graft and a membrane to obtain complete tissue reconstruction. The multidisciplinary POsTURE project aims to develop an innovative periodontal regeneration device based on: (i) a self-setting injectable bone grafting material containing Sr, Mg or Si substituted CaP nanoparticles with enhanced bioactivity and (ii) a photo-cross-linked interpenetrating polymer network based on UV photosensitive methacrylated dextran that will be applied as a viscous solution and cured in situ with UV light, as a membrane to prevent excessive proliferation of gingival tissue.

National Research Program of Latvia 2014-2017 within program No.6 project No.4 “Investigation of geological resources – new products and technologies (Earth)” subproject No.4

Subproject leader: Dr.sc.ing. Līga Bērziņa-Cimdiņa, RTU Institute of General Chemical Engineering

The aim of this project is to investigate and evaluate the application of Latvian clays in development of new products. Porous granular sorbent for water purification technology and sprayable biodegradable composite material for daily waste cover in landfills will be developed, as well as the ability of Latvian clays to stabilize emulsions and protect skin against UV radiation will be investigated.

National Research Programme No. 2014.10-4/VPP-3/21 “MultIfunctional Materials and composItes, photonicS and nanotechnology (IMIS2)” Project No. 4 “Nanomaterials and nanotechnologies for medical applications”

Project leader: Prof. Liga Berzina-Cimdina - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Develop new and improved innovative materials for medical applications, including implants for tissue replacement and regeneration, considering the fundamental and applied research results in the field and the latest advances in nanotechnology industry, as well as involving internationally recognized experts of various scopes with a motivated team of talented young scientists and specialists in coordinated research, while developing production and application technologies of new products through the capacity of newly established National Research Centers. Main project tasks:

  1. Creating and exploring new, exploitable and competitive biomaterials – nanostructured composite materials for bone and tissue implants.
  2. Develop and experimentally approbate new systems of optical biosensors for rapid microbiological quality control of food and environmental samples.
  3. Creating and exploring new, exploitable and competitive nano- and micro- carriers for targeted drug transport.

4.1. Subproject
Subproject leader: Assoc. Prof., Dr.sc.ing. Dagnija Loca - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Project aims to create and comprehensively characterize, including the in vitro and in vivo studies, new anti-bacterial and anti-osteoporotic biomaterials for regeneration of bones. Direction of the research aimed to solving the problem of an aging population, affecting people whose quality of life and mobility is dependent on musculoskeletal system diseases caused by bone dysfunction, which is the second most common cause of disability globally. In vivo and clinic studies of biphasic CaP bioceramic realized within the previous NRP have demonstrated a fundamental dependence of materials properties on the structural condition of patient's hard tissues as well as the dual effect of materials (increasing the reduced volume of atrophic bone through osteointegration, and the possibility of an osteoporotic bone remineralisation/reossification) into the bone tissues environment through long-term (more than five years) observations, paving the way to a novel treatment of osteoporosis locally. Modification of the CaP designed structurally by changing structural elements of the implant material from macro- to nano- levels or chemically by incorporating various substitutes and chemical elements that would provide specific desirable properties of the material allows developing alternative multifunctional biomaterials for the replacement or the reconstruction of functionality of various tissues.

RTU Scientific Research Project "Development of Production Method for High-Performance Nano-concrete with Low Water/Cement Ratio" (2018)

Project Leader. Project leader: Prof. Dr.sc.ing. Diana Bajare, Department of Building Materials and Products, Institute of Materials and Structures
Project Partner. Leader: Dr.sc.ing. Liga Stipniece, Institute of General Chemical Engineering

The project is planned to be implemented in cooperation between two RTU structural units - Department of Building Materials and Building Products, Institute of Materials and Structures and Institute of General Chemical Engineering (IGCE). The aim of the project is to develop a method for the production of high-performance nano-concrete by partly replacing with mineral, industrial by-products and production residues and thus reducing the amount of cement used, thereby promoting resource efficiency and increasing the environmental sustainability of products. Considering that the costs of production of cement are continuously increasing with the increase in the costs of electricity, it is expected that the introduction of high-performance nano-concrete production technology will significantly improve the economic performance of the merchant's business and increase competitiveness in the construction sector. The role of the IGCE is to determine the chemical and mineralogical composition of the raw materials used, as well as to study the binder and nano- or microfillers systems in order to create optimal compositions and to provide efficient cement hydration processes.

Cooperation project between RTU and RSU “Development of nanostructured bone replacement materials and study of immunological aspects in bone tissue regeneration" (2016-2019).

Project leader: Assoc. Prof., Dr.sc.ing. Janis Locs - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Aim of the project is to develop several innovative technologies for bone regeneration. At first technology for obtaining of amorphous calcium phosphate and nanostructured calcium phosphate granules with high specific surface area (> 50 m2/g) will be developed. The obtained materials will go through in vitro and in vivo tests. Practical use of the nanostructured granules is foreseen in stomatology and plastic surgery. Secondly, new diagnostic methods for characterization of bone regeneration rate using biological material (e.g. blood, serum, biopsy) will be developed.

ERDF project (1.1.1.1/16/A/144) "Influence of the magnetic field initiated stirring on biotechnological processes" (2017-2019).

Project Leader. Leader: Dr. Juris Vanags, Latvian State Institute of Wood Chemistry, Bioengineering laboratory
Project Partner. Leader: Assoc. Prof., Dr.sc.ing. Dagnija Loca - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The aim of the project is to investigate the influence of the created field of the magnetic field initiated stirring on the growth and biosynthesis of microorganisms. Based on this information, determine the usability boundaries of magnetic drive for various sterile biotechnological processes. The conditions of sterility are crucial for the biotechnological processes. One of the most typical contamination points of the bioreactor is stirring drive mechanical sealing. For solving this problem, the magnetic drive stirrers are used. As a result, microorganisms circulate in direct contact with the magnetic rotor. Despite the perspective of this kind of application, no unequivocal information about the influence of the magnetic field-initiated mixing on microorganism growth and biosynthesis is available. Within the framework of the project, RTU is performing cultivation of mammalian cells and calculations of reactor scaling in connection with the use of magnetic rotors.

Multifunctional nano-calcium phosphate/hyaluronic acid hydrogels for osteoporotic bone treatment

Project leader: Assoc. Prof., Dr.sc.ing. Dagnija Loca - RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The project aims to develop new, innovative three-dimensional calcium phosphate and hyaluronic acid cross-linked hydrogels with inorganic component up to 60 weight %, which would not cause inflammation in the surrounding tissues, promote angiogenesis processes and form new bone tissues. The scientific cooperation between Riga Biomaterials Innovations and Development Centre and Department of Pharmaceutical Chemistry of the Faculty of Pharmacy will provide in vitro and in vivo evaluation of the developed materials.

H2020 WIDESPREAD-04-2017- Teaming Phase 1 Project No. 763721 “Baltic Biomaterials Centre of Excellence”(2017-2018).

Project leader: Asoc.prof. Dr.sc.ing. Janis Loss, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

Establishment of the Baltic Biomaterials Centre of Excellence (BBCE) under Horizon 2020 Teaming framework will provide an opportunity to combine expertise and infrastructure, to create critical mass and excel in the respective field and create spill-over effects between different fields. Hence BBCE project´s main objective is to establish a joint Baltic Biomaterials Centre of Excellence for advanced biomaterial development based on the long-term strategic cooperation between AO Research Institute Davos, Switzerland (ARI) and Friedrich-Alexander University of Erlangen- Nuremberg, Germany (FAU) on the one hand and three institutions from Latvia - The Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of Riga Technical University (RTU RBIDC), Latvian Institute of Organic Synthesis (LIOS) and Riga Stradins University, (RSU) on the other hand. The funding has been received for business plan development.

Development of innovative frost-durable concrete by using rubber microgranules

Project Leader. Leader: Dr.sc.ing. Genādijs Šahmenko, Institute of Materials and Structures
Project Partner. Leader: Dr.sc.ing. Kristaps Rubenis, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The aim of this project is to develop ready-to-use, economically viable concrete compositions with enhanced frost durability, by using rubber microgranules obtained from scrap tires to enhance frost durability of the concrete.  

Energy production from the food waste (2018)

Project Leader. Leader: Dr.sc.ing. Kristīne Ruģele, RTU Water Research Laboratory
Project Partner. Leader: Dr.sc.ing. Olita Medne, Institute of General Chemical Engineering

The project aims to develop a technology for the treatment of food waste with a high concentration of fats for biogas production. The scientific cooperation will be fostered between Institute of General Chemical Engineering and Water Research laboratory.

ERA-NET EU-LAC Health projekts “Efficient and affordable water treatment technologies to minimise waterborne diseases. (2018-2020).

Project Leader. Leader: Linda Mežule, Water Research laboratory
Project Partner. Leader: Asoc.prof. Dr.sc.ing. Janis Loss, RTU Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Institute of General Chemical Engineering

The project aims to produce and demonstrate on a field- scale several point -of-use water treatment technologies that will be specially targeted to rural communities, affordable and easy to use. Within the project specially coated membranes with increased efficiency, titanium oxides electrodes and novel hybrid UV microfiltration system will be designed and evaluated for their efficiency to neutralize bacterial, viral and protozoan pollution. 

 

Other finished projects:

EU and international programs
National Research Program Projects
Internships abroad
Contract work
RTU research projects